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FCE8: Our Mouth is Not Vegas: What Happens Here Does Not Stay Here

October 30, 2022 @ 10:45 am - 12:15 pm


Fusanori Nishimura

Mark I. Ryder


Joan Otomo-Corgel

Atsushi Saito

The impact of periodontal inflammation and its treatment produces varying effects on systemic
diseases. The first section will present how periodontal inflammation induces insulin resistance via low-grade inflammation. Thus, periodontal treatment towards these subjects would help life-style intervention, leading to improved insulin sensitivity by the mechanism independent of direct effect driven by resolution of inflammation.


The second section will present new and compelling evidence that bacteria, viruses, and their products found in dental plaque may invade the brain where they may be a key early triggering event in Alzheimer’s Disease, as well as other forms of cognitive impairment/dementia.  These include the most up-to-date results from ongoing and completed clinical trials that target these pathogens. The practitioner will learn how these important new developments can be used in a “personalized dentistry” approach to their patients with or at risk for dementia.

Educational Objectives:
• Recognize the differences of the impact of low-grade inflammation on systemic health between the overall US population and Asian Americans.
• Learn about the effect of low-grade inflammation on thermogenesis.
• Understand the underlying biology of how the microflora associated with periodontal disease can lead to Alzheimer’s Disease development and progression.
• Learn how new studies using focused anti-bacterial therapies can slow the cognitive decline in patients with early dementia.
• Understand how the results of these new studies can be incorporated into a “personalized dentistry” approach for the periodontal patient at risk for Alzheimer’s Disease.


October 30, 2022
10:45 am - 12:15 pm
Program Track:


American Academy of Periodontology